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Nanotechnology in Construction Materials: Developments in Cement-Based Systems

為了解決Prada的問題，作者Cerro-Prada, Elena 這樣論述：

Calcium silicate hydrate, as the principal component of the hydration of Portland cement, has been the topic of intensive research over the past several years. An understanding of the nature of this hydration product at the nanoscale is essential for the strategic modification of conventional cement

-based systems and the development of new materials with enhanced properties. This book will explore this topic and how to enhance concrete functionalities utilizing nanotechnology. Dr. Elena Cerro-Prada received her PhD in Physics from the Autonoma University of Madrid. She lectured at the Unive

rsity of Birmingham, UK, and worked at CERN within the Nobel Laureate Carlo Rubia, among other research and academic positions. Dr Cerro-Prada currently serves as Professor and Head of the Physics Department at the Technical University of Madrid. Dr. Cerro-Prada has contributed greatly to the unders

tanding of cementitious materials microstructure by applications of nanotechnology and nanomaterials. She is currently involved in the development of cement-based materials with photocatalytic properties as long as agent-based cementitious material modeling.

Prada進入發燒排行的影片

Pharmacoinformatic analysis and preclinical evaluation of a novel first-in class onco-immunotherapeutic small molecule for the treatment of non-small-cell lung cancer (NSCLC)

為了解決Prada的問題，作者Bashir Lawal 這樣論述：

Lung cancer poses a serious threat to human health and has recently been tagged the most common malignant disease with the highest incidence and mortality rate. Although epidermal growth factor (EGFR)-tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of advanced non-small

cell lung cancer (NSCLC) patients with EGFR mutations often develop resistance to these drugs. There is therefore a need to identify new drug candidates with multitarget potential for treating NSCLC. We hereby provide preclinical evidence of the therapeutic efficacy of NLOC-015A a multitarget first-

in class small-molecule inhibitor of EGFR/mitogen-activated protein (MAP) kinase kinase 1 (MAP2K1)/mammalian target of rapamycin (mTOR)/yes-associated protein 1 (YAP1) for the treatment NSCLC. Our multi-omics analysis of clinical data from cohorts of NSCLC revealed that dysregulation of EGFR/MEK1/mT

OR/YAP1 signaling pathways was associated with the progression, therapeutic resistance, immune-invasive phenotypes, and worse prognoses of NSCLC patients. Analysis of single-cell RNA sequencing datasets revealed that MAP2K1, mTOR, YAP1 and EGFR were predominantly located on monocytes/macrophages, Tr

eg and exhaustive CD8 T cell, and are involved in M2 polarization within the TME of patients with primary and metastatic NSCLC which further implied gene’s role in remodeling the tumor immune microenvironment. A molecular-docking analysis revealed that NLOC-015A bound to YAP1, EGFR, MEK1, and mTOR w

ith strong binding efficacies ranging –8.4 to –9.50 kcal/mol. Interestingly, compared to osimertinib, NLOC-015 bound with higher efficacy to the tyrosine kinase (TK) domains of both T790M and T790M/C797S mutant-bearing EGFR. Our in vitro studies revealed that NLOC-015A inhibited the proliferation an

d oncogenic properties of NSCLC with concomitant downregulation of EGFR/MAP2K1/mTOR/YAP1 signaling networks. In addition, the stemness inhibitory effect of NLOC0-15A was accompanied by decreased expression levels of aldehyde dehydrogenase (ALDH), c-Myc, and SOX2 in both H1975 and H1299 cell lines. F

urthermore, NLOC-015A suppressed the tumor burden and increased the body weight and survival of H1975 xenograft-bearing mice. Interestingly, NLOC-015A synergistically enhanced the anti-NSCLC activities of osimertinib both in vitro and in vivo models. We, therefore, suggest that NLOC-015A might repre

sent a new candidate for treating NSCLC via acting as a multitarget inhibitor of EGFR, mTOR/NF-κB, YAP1, MEK1 in NSCLC.

The Velvet Rose

為了解決Prada的問題，作者 這樣論述：

Susan Holmes McKagan is a well-known, experienced, and credentialed writer. Her columns regularly appear on the coveted front-page cover stories for The Huffington Post and PopWrapped. She also happens to be an international supermodel, having graced covers for Vogue, Glamour, Cosmopolitan, Marie Cl

aire, W, Playboy, and Maxim to name a few. Susan has walked the catwalks in Paris, Milan, and New York for such prestigious designers as Chanel, Versace, Prada, Calvin Klein, Valentino, Marc Jacobs, YSL, Armani, and many more. She’s been married for nearly two decades to Rock & Roll Hall of Fame leg

end Duff McKagan of Guns N’ Roses and Grammy Award-winning Velvet Revolver. Susan writes on a myriad of subjects, and has a plethora of published top-tier interviews with some of the world’s leading artists, athletes, humanitarians, scientists, celebrities, designers, authors, and musicians. She dev

elops and designs her own high-end brand of eco-friendly resort wear, Susan Holmes Swimwear, and her designs have been featured on covers from Sports Illustrated to People magazine. While living on the West Coast between her homes in Seattle, Los Angeles, and San Diego--or on a GN’R airplane--Susan

dedicates most of her time to her two daughters, various charitable organizations, her incorrigibale but cute pug, and her sweet husband.

泰國警察來台就讀研究所動機與適應問題之研究

為了解決Prada的問題，作者汪文芳 這樣論述：

Thai police officers are becoming more and more interested in pursuing a master's degree overseas, and many Thai police officers have chosen to study for a master's degree in Taiwan. The purpose of this research is to investigate the factors that influence decision-making or motivate Thai police of

ficers to pursue a master's degree in Taiwan, as well as the obstacles and problems they encounter while living in Taiwan, and how to deal with them.This research used a qualitative semi-structured interview method. In this research, researcher interviewed six Thai police officers who are studying f

or a master's degree in Taiwan. The interview questions are divided into five parts as follows: Background information on Thai police officers, the factors or motivations, the problems and obstacles, management and solving problems encountered during their stay in Taiwan, and achievements related to

a career. Based on the research results, the factor that most influenced the decision-making of Thai police officers is financial cost issues. The problem and barrier that affected their lives the most is the weather and the solution is to ask friends or classmates.Keywords: Thai Police Officer, St

udy Motivation, Factors