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Her Honor: My Life on the Bench...What Works, What’’s Broken, and How to Change It

為了解決Registry的問題，作者Cordell, Ladoris Hazzard 這樣論述：

Judge LaDoris Hazzard Cordell is a legal commentator and police reform advocate, who is a frequent commentator on news outlets including NPR, CNN, and MSNBC. A graduate of Stanford Law School, she became the first African American woman jurist in Northern California, a position she held from 1982 to

2001. Prior to her time on the bench, she was the first lawyer to open a private practice in East Palo Alto, CA, a low-income community of color, and was an Assistant Dean of Stanford Law School where she implemented a highly successful minority admissions program. Following her retirement from the

bench, she was a Vice Provost at Stanford University and, in 2010, was appointed the Independent Police Auditor for the City of San Jose. Judge Cordell’s public service record spans decades, during which time she has overseen commissions that investigated violence and mental health care in the jail

system, as well as accounts of racism in the San Francisco police department. She has received numerous awards, including Silicon Valley NAACP’s William E.B. Dubois Award, the Iola Williams Public Service Award, the National Council of Negro Women’s Public Service Award, the Social Justice Award fr

om Legal Advocates for Children & Youth, and the Rose Bird Memorial Award from the California Women Lawyers. Judge Cordell founded the African American Donor Task Force to increase black participation in the national bone marrow registry. She is the co-founder of the African American Composer Initia

tive and CA Parks for All. An artist and pianist, she resides in California with her partner and is the proud mother of two daughters.

Registry進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Registry的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Student Support Services

為了解決Registry的問題，作者 這樣論述：

Dr. Padro has a double major doctorate in the areas of academic administration and curriculum and instruction. After having served as Associate Professor in the Doctoral Program and Interim Director of Educational Leadership at Cambridge College, he is currently a Senior Lecturer (Quality) at the Un

iversity of Southern Queensland (USQ). In addition, he is currently on Australia’s Tertiary Education Quality Standards Agency’s (TEQSA) Registry of Experts (2013-2016), is Chair of the American Society for Quality (ASQ - 2013 through 2014), Editor of the e-journal Quality Approaches in Higher Educa

tion (ASQ Education Division), a member of the International Network of Quality Assurance Agencies in Higher Education’s (INQAAHE) Best Practice QA Review Team, member of the International Standards Organization (ISO) ISO/TC 176 Working Group, member of the Editorial Board of The TQM Journal (Emeral

d), and reviewer for the Total Quality Management & Business Excellence Journal (Routledge).

台中港區微粒、金屬元素之乾沉降污染物預測、排放來源及健康風險評估之研究

為了解決Registry的問題，作者高偉順 這樣論述：

本研究是使用PS-1採樣器與乾沉降板來蒐集大氣中的懸浮微粒及其附屬重金屬汙染物之濃度及乾沉降，採樣時間於2020年1月至12月於台中梧棲港區來進行。本研究並藉由使用ICP-OES分析儀來分析附著於懸浮微粒上之汙染物的重金屬濃度及乾沉降。再者，本研究亦使用Global model來推估並比較不同粒徑所計算出來之懸浮微粒及其附屬重金屬汙染物之乾沉降通量，其值並與實際之乾沉降值作一比較。除此之外，本研究並利用逆軌跡分析方法來推測台中港區採樣點之可能汙染源。最後，本研究更以風險評估之方法來計算該特徵採樣點之致癌風險值。研究結果顯示，總懸浮微粒濃度與乾沉降通量其最高值均發生於冬季，而重金屬濃度與乾沉降

之最高值則分別為重金屬Cu，Ni。此外，乾沉降模式之研究結果顯示，Global collection model之模式推估乾沉降通量以重金屬元素Pb可得到最佳之乾沉降推估結果。再者，重金屬元素Pb 乾沉降通量之最佳預測結果則出現在 以16 μm 的微粒尺寸作為計算之乾沉降速度則其乾沉降通量能有最佳之推估結果。而逆軌跡分析之結果顯示，本研究之主要汙染氣團於6、7、8月是來自採樣點的南方，其餘月份皆來自於採樣點之北方。而在健康風險評估結果顯示該採樣點之金屬元素Cr的致癌風險值結果高於1×10-4，上述值高於致癌風險監管機構US/EPA之標準。因此，未來宜持續監測觀察上述重金屬Cr元素於台中港區之濃

度及致癌風險值。