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Lonely Planet Best of Southeast Asia

為了解決day&day的問題，作者Lonely Planet 這樣論述：

Lonely Planet’s Best of Southeast Asiais your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. Watch sunrise at Angkor’s temples, learn Thai cooking in Bangkok or cruise Halong Bay; all with your trusted travel companion. Discover th

e best of Southeast Asia and begin your journey now!Inside Lonely Planet’s Best of Southeast Asia: Up-to-date information - all businesses were rechecked before publication to ensure they are still open after 2020’s COVID-19 outbreakFull-colour images throughoutHighlightsand itineraries help you tai

lor your trip to your personal needs and interestsInsider tips to save time and money and get around like a local, avoiding crowds and trouble spotsEssential infoat your fingertips - hours of operation, phone numbers, websites, transit tips, pricesHonest reviews for all budgets - eating, sightseeing

, going out, shopping, hidden gems that most guidebooks missCultural insights give you a richer, more rewarding travel experience - history, art, food, wine, sport, landscapes, wildlifeCovers Halong Bay (Vietnam), Hoi An (Vietnam), Luang Prabang (Laos), Si Phan Don (Laos), Phnom Penh (Cambodia), Ang

kor (Cambodia), Bangkok (Thailand), Chiang Mai (Thailand), Bagan (Myanmar), Yangon (Myanmar), Penang (Malaysia), Semporna Archipelago (Malaysia), Singapore, Borobudur & Prambanan (Indonesia), Bali (Indonesia), Palawan (Philippines), Gunung Mulu National Park (Malaysia), Komodo National Park (Ind

onesia)The Perfect Choice: Lonely Planet’s Best of Southeast Asia, our easy-to-use guide, filled with inspiring and colourful photos, focuses on Southeast Asia’s most popular attractions for those looking for the best of the best.Looking for a comprehensive guide that recommends both popular and of

fbeat experiences, and extensively covers all the country has to offer? Check out Lonely Planet’s Southeast Asia guide.Looking for a guide for Bangkok? Check out Lonely Planet’s Bangkok for a comprehensive look at all this city has to offer, or Pocket Bangkok, a handy-sized guide focused on the can

’t-miss sights for a quick trip.About Lonely Planet: Lonely Planet is a leading travel media company, providing both inspiring and trustworthy information for every kind of traveller since 1973. Over the past four decades, we’ve printed over 145 million guidebooks and phrasebooks for 120 languages,

and grown a dedicated, passionate global community of travellers. You’ll also find our content online, and in mobile apps, videos, 14 languages, armchair and lifestyle books, ebooks, and more, enabling you to explore every day. ’Lonely Planet guides are, quite simply, like no other.’ â New York Time

s’Lonely Planet. It’s on everyone’s bookshelves; it’s in every traveller’s hands. It’s on mobile phones. It’s on the Internet. It’s everywhere, and it’s telling entire generations of people how to travel the world.’ â Fairfax Media (Australia)

Lonely Planet Dubai & Abu Dhabi 10

為了解決day&day的問題，作者Schulte-Peevers, Andrea,Raub, Kevin 這樣論述：

Inside Lonely Planet’s Dubai and Abu Dhabi Travel Guide: What’s NEW in this edition?Up-to-date information - all businesses were rechecked before publication to ensure they are still open after 2020’s COVID-19 outbreakHighlightsand itineraries help you tailor your trip to your personal needs and

interestsEating & drinking in Dubai and Abu Dhabi - we reveal the dishes and drinks you have to tryDubai and Abu Dhabi’sbeaches - whether you’re looking for relaxation or activities, we break down the best beaches to visit and provide safety informationColour maps and images throughoutInsider ti

ps to save time and money and get around like a local, avoiding crowds and trouble spotsHonest reviews for all budgets - eating, sleeping, sightseeing, going out, shopping, hidden gems that most guidebooks missCultural insights give you a richer, more rewarding travel experience - history, people, m

usic, landscapes, wildlife, politicsOver32mapsCovers Deira, Bur Dubai, Downtown Dubai, Jumeirah & Around, Dubai Marina & Palm Jumeirah, Abu Dhabi, Sharjah, Al Ain, UAE East CoastThe Perfect Choice: Lonely Planet’s Dubai and Abu Dhabi, our most comprehensive guide to the region, is perfect f

or both exploring top sights and taking roads less travelled.Visiting Dubai and Abu Dhabi for a week or less? Lonely Planet’s Pocket Dubai and Pocket Abu Dhabi are handy-sized guide focused on the cities’ can’t-miss experiences.eBook Features: (Best viewed on tablet devices and smartphones)Downloada

ble PDF and offline maps prevent roaming and data chargesEffortlessly navigate and jump between maps and reviewsAdd notes to personalise your guidebook experienceSeamlessly flip between pagesBookmarksand speedy search capabilities get you to key pages in a flashEmbedded links to recommendations’ web

sitesZoom-in maps and imagesInbuilt dictionary for quick referencingAbout Lonely Planet: Lonely Planet is a leading travel media company, providing both inspiring and trustworthy information for every kind of traveller since 1973. Over the past four decades, we’ve printed over 145 million guidebooks

and phrasebooks for 120 languages, and grown a dedicated, passionate global community of travellers. You’ll also find our content online, and in mobile apps, videos, 14 languages, armchair and lifestyle books, ebooks, and more, enabling you to explore every day.’Lonely Planet guides are, quite simp

ly, like no other.’ - New York Times’Lonely Planet. It’s on everyone’s bookshelves; it’s in every traveller’s hands. It’s on mobile phones. It’s on the Internet. It’s everywhere, and it’s telling entire generations of people how to travel the world.’ - Fairfax Media (Australia)

Dapagliflozin在鏈脲佐菌素誘發糖尿病鼠因內毒素引發敗血症及急性腎衰竭作用探討

為了解決day&day的問題，作者紀伯叡 這樣論述：

背景：敗血症是身體對感染所產生失調的發炎反應。敗血症通常會合併急性腎臟損傷，與高死亡率及高罹病率習習相關。Dapagliflozin是一種新的口服降血糖藥物，屬於第二型鈉-葡萄糖轉運蛋白抑制劑(sodium-glucose cotransporter 2 inhibitor, SGLT2i)，可以減少近端腎小管對鈉及糖的回收，達到降血糖目的。然而，最近大型臨床試驗發現，第二型鈉-葡萄糖轉運蛋白抑制劑除了降血糖之外，還可以降血壓，減少糖分毒性，達到血液動力學穩定效果，進一步改善心血管以及腎臟相關死亡結果，這效果可能並非單純來自於血糖改善因素，可能與降低發炎反應相關。因此，本研究分兩個部分進行。

第一部分利用第一型糖尿病小鼠模式，用內毒素(lipopolysaccharide, LPS)引發敗血症及急性腎損傷，研究dapagliflozin在第一型糖尿病小鼠因敗血症引起的急性腎損傷的影響(研究一)，再利用細胞實驗分析其中可能的機轉(研究二)。方法：在研究一中，24隻六週大的C57BL6小鼠隨機分為三組。DM + LPS組(n=8) ： 腹腔注射150 mg/kg streptozotocin誘發糖尿病後給予靜脈注射內毒素10mg/kg引發敗血症及急性腎損傷; DM + LPS + Dapagliflozin組(n=8) ：腹腔注射150 mg/kg streptozotocin誘發糖尿

病後給予靜脈注射內毒素10mg/kg引發敗血症及急性腎損傷，再給予靜脈注射10mg/kg dapagliflozin。Vehicle組(n=8) ：為對照組，不誘發糖尿病，僅給予生理食鹽水當安慰劑靜脈注射。觀察48小時後犧牲採血及組織。研究二中，我們使用NRK-52E細胞株添加LPS下，使用dapagliflozin與否來比較，以找尋可能的保護機轉。結果：研究一顯示，dapagliflozin改善第一型糖尿病小鼠因內毒素引發敗血症造成的急性腎損傷，包括血中blood urea nitrogen、creatinine及transcutaneous glomerular filtration ra

te改善。組織方面，dapagliflozin可以改善第一型糖尿病小鼠因內毒素引發敗血症造成的腎小管損傷，腎臟kidney injury molecule-1的增加及E-cadherin下降。dapagliflozin減少第一型糖尿病小鼠因內毒素引發敗血症時全身性Tumor necrosis factor-α，interleukin(IL)-1β及IL-6增加。這些結果顯示dapagliflozin可以減少第一型糖尿病小鼠因內毒素引發敗血症造成的全身發炎反應以及減少因內毒素引發敗血症造成的急性腎臟損傷。研究二NRK-52E細胞株的細胞實驗顯示，dapagliflozin在LPS下會活化aden

osine monophosphate -activated protein kinase (AMPK)，nuclear factor erythroid-2-related factor，heme oxygenase 1表現，dapagliflozin改善LPS引起的發炎前細胞激素(pro-inflammatory cytokine)表現、減少活性氧化物質(reactive oxygen species)產生。結論：動物實驗表明，dapagliflozin在第一型糖尿病小鼠可以有效減輕內毒素引發敗血症的全身性發炎反應，以及敗血症造成的急性腎臟損傷。分生機轉研究顯示，透過活化腎臟細胞內AMPK

途徑，緩解發炎前細胞激素，減少活性氧化物質，推論dapagliflozin對第一型糖尿病小鼠因敗血症引起急性腎臟損傷可能有保護作用。